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For 15 years, J. Craig Venter has chased a dream: to build agenome from scratch and use it to make synthetic life. Now,he and his team at the J. Craig Venter Institute (JCVI) in Rockville,Maryland, and San Diego, California, say they have realizedthat dream. In this week's Science Express (www.sciencemag.org/cgi/content/abstract/science.1190719),they describe the stepwise creation of a bacterial chromosomeand the successful transfer of it into a bacterium, where itreplaced the native DNA. Powered by the synthetic genome, thatmicrobial cell began replicating and making a new set of proteins.

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"Another step closer to Grey Goo Apocalypse Now?" - Jack Sarfatti