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ABSTRACT

Although theories regarding the role of sequence-specific DNA resonance in biology have abounded for over40 years, the published evidence for it is lacking. Here, the authors reasoned that for sustained resonancesignaling, the number of oscillating DNA sequences per genome should be exceptionally high and that,therefore, genomic repeats of various sizes are good candidates for serving as resonators. Moreover, it wassuggested that for the two DNA sequences to resonate, they do not necessarily have to be identical.Therefore, the existence of sequences differing in the primary sequence but having similar resonatingsub-structures was proposed. It was hypothesized that such sequences, named HIDERs, would be enriched inthe genomes of multicellular species. Specifically, it was hypothesized that delocalized electron clouds ofpurine-pyrimidine sequences could serve as the basis of HIDERs. The consequent genomic analysisconfirmed the enrichment of purine-pyrimidine HIDERs in a few selected genomes of mammals, an insect, anda plant, compared to randomized sequence controls. Similarly, it was suggested that hypothetical delocalizedproton clouds of the hydrogen bonds of multiple stacked bases could serve as sequence-dependenthydrogen-bond-based HIDERs. Similarly, the enrichment of such HIDERs was observed. It is suggested thatthese enrichments are the first evidence in support of sequence-specific resonance signaling in the genome.

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Category: Science