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Genomic sequencing has revolutionized our understanding of medicine and evolution, such as identifying hereditary anomalies. Arrays of nanometer-sized holes—nanopores—in silicon nitride can in principle dramatically speed up and lower the cost of such analyses. However, DNA molecules transit such nanopores far too quickly for detection, causing only weak signals that are often difficult to analyze. Now, a research study led by The Institute of Scientific and Industrial Research (SANKEN) at Osaka University has utilized a method to enhance DNA detection in nanopores by manipulating the electrical properties of the DNA within and slowing down its transit.

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