Proteins normally recognize each other by their specific 3-D structure. If the key fits in the lock, a reaction can take place. However there are reactions at the onset of which the key does not really have a shape. German chemists at the Technische Universitaet Muenchen and the Max Planck Research Unit for Enzymology of Protein Folding (Halle/Saale) have now shown how this might work. Their results will appear in PNAS this week.

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