The mythical dragon has been associated with Wales for more than a millennium and famously graces the national flag.
But is it possible dragons could ever exist beyond the pages of Celtic mythology or the celluloid of fantasy film?
Academics have suggested in a recent essay the creation of large, winged dragons using cutting-edge genome editing is not beyond the realms of possibility.
Is the seemingly far-fetched idea a flier or, like dragon's breath, just hot air? The BBC asked the authors.
'Not impossible'
The essay in The American Journal of Bioethics said spectacular animals could be brought to life using a targeted gene-editing system known as CRISPR-CAS9.
Co-authors Prof Hank T Greely, director of the Centre for Law and the Biosciences at Stanford Law School, and Prof R Alta Charo, Professor of Bioethics and Law at Wisconsin Law School, said their dragon suggestion was "somewhat tongue-in-cheek" but "not impossible".
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