It's a strong contender for the geekiest video ever made: a close-up of a smartphone with line upon line of numbers and symbols scrolling down the screen. But when visitors stop by Nicola Marzari's office, which overlooks Lake Geneva, he can hardly wait to show it off. “It's from 2010,” he says, “and this is my cellphone calculating the electronic structure of silicon in real time!”

Even back then, explains Marzari, a physicist at the Swiss Federal Institute of Technology in Lausanne (EPFL), Switzerland, his now-ancient handset took just 40 seconds to carry out quantum-mechanical calculations that once took many hours on a supercomputer — a feat that not only shows how far such computational methods have come in the past decade or so, but also demonstrates their potential for transforming the way materials science is done in the future.

Instead of continuing to develop new materials the old-fashioned way — stumbling across them by luck, then painstakingly measuring their properties in the laboratory — Marzari and like-minded researchers are using computer modelling and machine-learning techniques to generate libraries of candidate materials by the tens of thousands. Even data from failed experiments can provide useful input1. Many of these candidates are completely hypothetical, but engineers are already beginning to shortlist those that are worth synthesizing and testing for specific applications by searching through their predicted properties — for example, how well they will work as a conductor or an insulator, whether they will act as a magnet, and how much heat and pressure they can withstand.

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