Today, I want to riff on Sean Carroll's stimulating contribution to 13.7 this past weekend by bringing up a few open scientific questions that are particularly baffling.

These are the kinds of questions that may not be answerable, which brings us to the complementary side of the fear of knowing — the fear of not knowing. How do we deal with questions that have no answers? They also play an essential part in our search for meaning, be it through the sciences, the arts and, of course, different modes of spiritual devotion.

Let me first write down the challenges (possible unknowables) and then list what it would take to overcome them from a scientific perspective:

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