Huddled in a coffee shop one drizzly Seattle morning six years ago, the astrobiologist Shawn Domagal-Goldman stared blankly at his laptop screen, paralyzed. He had been running a simulation of an evolving planet, when suddenly oxygen started accumulating in the virtual planet’s atmosphere. Up the concentration ticked, from 0 to 5 to 10 percent.

“Is something wrong?” his wife asked.

“Yeah.”

The rise of oxygen was bad news for the search for extraterrestrial life.

After millennia of wondering whether we’re alone in the universe — one of “mankind’s most profound and probably earliest questions beyond, ‘What are you going to have for dinner?’” as the NASA astrobiologist Lynn Rothschild put it — the hunt for life on other planets is now ramping up in a serious way. Thousands of exoplanets, or planets orbiting stars other than the sun, have been discovered in the past decade. Among them are potential super-Earths, sub-Neptunes, hot Jupiters and worlds such as Kepler-452b, a possibly rocky, watery “Earth cousin” located 1,400 light-years from here. Starting in 2018 with the expected launch of NASA’s James Webb Space Telescope, astronomers will be able to peer across the light-years and scope out the atmospheres of the most promising exoplanets. They will look for the presence of “biosignature gases,” vapors that could only be produced by alien life.

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