As we enter a new era in space travel, a study looking at how the human brain reacts to traveling outside Earth's gravity suggests frequent flyers should wait three years after longer missions to allow the physiological changes in their brains to reset.

Researchers studied scans of 30 astronauts from before and after . Their findings, reported in Scientific Reports, reveal that the brain's ventricles expand significantly in those who completed longer missions of at least six months, and that less than three years may not provide enough time for the ventricles to fully recover.

Ventricles are cavities in the brain filled with , which provides protection, nourishment and waste removal to the brain. Mechanisms in the effectively distribute fluids throughout the body, but in the absence of gravity, the fluid shifts upward, pushing the brain higher within the skull and causing the ventricles to expand.

"We found that the more time people spent in space, the larger their ventricles became," said Rachael Seidler, a professor of applied physiology and kinesiology at the University of Florida and an author of the study. "Many astronauts travel to space more than one time, and our study shows it takes about three years between flights for the ventricles to fully recover."

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