A new molecular engineering technique can precisely influence the development of organoids. Microbeads made of specifically folded DNA are used to release growth factors or other signal molecules inside the tissue structures. This gives rise to considerably more complex organoids that imitate the respective tissues much better and have a more realistic cell mix than before.
An interdisciplinary research team from the Cluster of Excellence "3D Matter Made to Order" with researchers based at the Center for Organismal Studies and the Center for Molecular Biology of Heidelberg University, the university's BioQuant Center as well as the Max Planck Institute for Medical Research in Heidelberg developed the technique.
The research was published in the journal Nature Nanotechnology.
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