Most microscopes can only illuminate objects down to a certain size before tiny features blur together. This blurring is known as the diffraction limit of light. Super-resolution imaging techniques, however, can distinguish between tiny biomolecular features, especially when thermal fluctuations are minimized.
Using advanced imaging techniques and precise microfluidics control to stretch out curly DNA into a straight line, research published this week in AIP Advances, from AIP Publishing, demonstrates techniques for stretching and immobilizing DNA with minimum thermal fluctuation to enable detailed analysis.
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