Scientists have tapped into the Summit supercomputer to study an elaborate molecular pathway called nucleotide excision repair (NER). This research reveals how damaged strands of DNA are repaired through this molecular pathway, nucleotide excision repair.
NER’s protein components can change shape to perform different functions of repair on broken strands of DNA.
A team of scientists from Georgia State University built a computer model of a critical NER component called the pre-incision complex (PInC) that plays a key role in regulating DNA repair processes in the latter stages of the NER pathway.
Decoding NER’s sophisticated sequence of events and the role of PInC in the pathway could provide key insights into developing novel treatments and preventing conditions that lead to premature aging and certain types of cancer.
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