In The Hitchhiker’s Guide to the Galaxy, Douglas Adams imagined a supercomputer called Deep Thought, built by a race of hyper-intelligent beings to calculate the Answer to the Ultimate Question of Life, the Universe and Everything. After a mere seven and a half million years of computation, the machine finally revealed its answer: 42.

There was just one problem. Despite their hyper-intelligence, none of those beings understood what the question had been. The joke was that any answer – no matter how precise – is meaningless without a thorough understanding of both the question and the route taken to obtain the answer.

Yet what was once purely science fiction is beginning to sound unexpectedly relevant to modern research. From structural biology to particle physics, artificial intelligence (AI) systems are increasingly involved in research, providing results of remarkable power and accuracy. They are being used to identify hidden patterns in vast datasets, to generate hypotheses, to accelerate simulations and to guide experiments.

As AI becomes increasingly embedded in the scientific process, could we be entering an era of discoveries without understanding?

But in some cases, even the creators of those AI systems are struggling to explain exactly how the AI arrives at its  conclusions. All of which raises an uncomfortable possibility. As AI becomes increasingly embedded in the scientific process, could we be entering an era of discoveries without understanding? And if so, what happens when science starts producing its own versions of the answer “42”?

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